• IPA: /məˈlɪɡ.nən.si/

malignancy

1. The state of being malignant or diseased.
2. A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.
3. That which is malign; evil, depravity, malevolence.
   • c. 1601–1602, William Shakespeare, “Twelfe Night, or VVhat You VVill”, in Mr. William Shakespeares Comedies, Histories, & Tragedies: Published According to the True Originall Copies (First Folio), London: Printed by Isaac Iaggard, and Ed[ward] Blount, published 1623, OCLC 606515358 ↗, [Act II, scene i]:

     The malignancy of my fate might perhaps distemper yours.

• benignancy
• benignity